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These variations significantly influence the role of GLP-1 in regulating islet function and glucose homeostasis

Mechanistically, it influences gene networks involved in tissue remodeling and exerts protective antioxidant and anti-inflammatory actions, partly through TGF- signaling and regulation of metalloproteinases

In the consensus CTG model, the sensitivity, specificity, and CCR were 78%, 74%, 76%, respectively for CPT-1 and 82%, 77%, 79%, respectively for CPT-2 (Figure 5)

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Most importantly, growth hormone stimulates the production of insulin-like growth factor-1 (IGF-1), a powerful mediator of tissue growth and repair