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We are grateful to Dr Slava Ziegler for discussions of biological experiments

The phosphorylated Smad2/3 then connects and moves to Smad4, thereby triggering the transcription of genes responsive to TGF-

Compounds such as resveratrol (found in grapes) and curcumin (found in turmeric) have demonstrated the ability to activate HATs, promoting histone acetylation and thereby influencing gene transcription (Qi et al