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Therefore, LPS not only primes the inflammasome by upregulating IL-1 transcriptionally but also triggers post-translational K63-ubiquitin, K48-ubiquitin, and K11-ubiquitin chain modification of IL-1 that correlate with its proteasomal degradation at a rate comparable to other short-lived proteins, such as Mcl-1 25

Previously, mutations in several folate pathway genes, including FR, dihydrofolate reductase, and PCFT were identified in CFD patients [25]

Briefly, HeLa cells were incubated with Alexa 546-conjugated Tf (5g/ml in DMEM) at 37C for 2 hours to allow the steady-state accumulation of Tf in endosomes

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Baicalein directly interacts with TLR4 and inhibits the TLR4/HIF-1/VEGF signaling pathway in CRC