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Also, mucolytics can modify mucus in ways that might reduce its protective abilities, which raises concerns about a higher risk of infections or irritation, especially with long-term use

Tran C, Singh GV, Haider E, et al

The availability of the porcine and, perhaps, the ferret models of cystic fibrosis should greatly expedite the evaluation of these new CFTR pharmacotherapeutics and facilitate the identification of optimal drug combinations, doses and methods of delivery

In contrast, the main metabolic processes of Treg cells are ketone body mitochondrial oxidation and FAO oxidation

Moreover, the intestinal microbiota contributes to the progression of host diseases through its metabolites, including short chain fatty acids (SCFAs), bile acids, tryptophan, branched-chain amino acids, and uremic toxins [5]