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Acknowledgements This work was financially supported by the National Natural Science Foundation of China (Nos

doi: 10.3390/ijms22179474 158 TaurYJenqRRPeralesMALittmannERMorjariaSLingLet al

USA 87 , 71857189 (1990)

In Caco-2 cell monolayers and in vivo murine models, LA1 effectively attenuates TNF-induced TJ barrier disruption via a Toll-like receptor-2 (TLR2)dependent mechanism that suppresses NF-B p50/p65 activation