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doi: 10.3389/fendo.2023.1133000 Received 28 December 2022 Accepted 13 March 2023 Published 24 March 2023 Volume 14 - 2023 Edited by Silvia Martina Ferrari, University of Pisa, Italy Reviewed by Sabrina Rosaria Paparo, University of Pisa, Italy

Secondary trigeminal neuralgia (TN): It occurs when another condition damages or affects your trigeminal nerve, such as multiple sclerosis (MS), a tumor, or arteriovenous malformation

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The increase of intracellular ROS is believed to correlate with the activation of nuclear factor (NF)-kappa B, a transcription activator linked to the elaboration of several cytokines (Figure 6)

PNC-27 has not been evaluated by the MHRA, FDA, or any regulatory authority for safety or efficacy in humans or animals, and has not undergone or completed human clinical trials