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Roller et al., 2016)

It should be used with caution in neonates, premature infants, children, and adolescents (aged below 18 years) and is advised to be used with caution in elderly patients (aged 70 years and above) after consulting the doctor

A single-use injection vial does not carry that risk

Hepatitis B virus (HBV) infection is a major global health issue, driven by high levels of immunosuppressive viral antigens, the host immune system's failure to effectively control the virus, and the immunosuppressive environment of the liver