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Ferrer-Vaquer et al., To determine the functional significance of canonical Wnt signaling in prosensory cells, these authors first used small molecule inhibitors of Wnt signaling in organotypic cultures of the embryonic (E12.5) cochlea and found that inhibition of Wnt signaling results in decreased proliferation of prosensory cells (Jacques et al., Sox2 -expressing prosensory domain and an increase in hair cell number

Copper in cancer: from pathogenesis to therapy

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Of the 50 markers investigated, 4, 11 and 25 serum and plasma analytes were significantly different from controls in mild, moderate and severe groups, respectively after false discovery rate (FDR) correction and included several well-defined pro-inflammatory cytokines, including interferon- (IFN), interleukin-6 (IL-6), interleukin-1 (IL-1), interleukin-1RA (IL-1RA), interleukin-8 (IL-8) and 10 kDa interferon gamma-induced protein (IP-10)