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doi: 10.1002/advs.202100997 31 YuYJiangLWangHShenZChengQZhangPet al

A recent study indicates that endogenous H 2 O 2 production and oxidative stress leads to mitochondrial translocation of PGK1, where it phosphorylates alternative substrates 49

Primary endpoints Energy expenditure and RER under indirect calorimetry, fat mass and adipocyte size, liver triglyceride content and histology, plasma lipids, and muscle performance form a coherent endpoint suite tied to ERR biology

Results Metformin enhances the proliferation and neural differentiation of NSCs Primary NSCs were isolated from the cerebral cortex of E12-14 Wistar rat embryos and subsequently proliferated and aggregated to form neurospheres in the growth medium (Supplementary Fig

In some experiments, researchers observed lifespan extensions ranging from roughly 10% to 25%, depending on the species, age of the animals, and study design