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Common symptoms include: Angular Cheilitis (Angular Stomatitis) Angular cheilitis is a hallmark of Vitamin B deficiency, especially B2 (riboflavin) and B12

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In the first case, each enzyme of the pathway is knocked down in turn by feeding with bacteria expressing double stranded RNA (dsRNA) against them or by isolating deletion mutants

The study was subsequently amended to authorize the collection of additional biological samples (tissue, blood and fecal) and protocol v.2.1 (dated 19 February 2019) received approval on 13 June 2019 by both the coordinating and local ethics committees