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or in patients with chronic bronchitis where treatment periods were lengthy (1224 weeks) at doses of 400600 mg/day where NAC reduced the risk of exacerbations and improves symptoms in patients with chronic bronchitis compared with placebo (11 trials, 2,011 participants).(7) Clinical trial evidence for the use of NAC as an antioxidant in influenza and other acute viral respiratory tract infections is limited and relate to isolated small clinical trials

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Recent research has shown that rhein can alleviate changes in the renal microstructure of model rats, and decrease the expression of apoptosis-related proteins, thereby reducing cell apoptosis, and counteracting the damage caused by oxidative stress to the kidneys (184)

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