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Professional laser procedures are medically regulated and target melanin in a controlled way, while unregulated whitening creams often contain harmful ingredients

Psychopharmacology 169 (1), 108114

While macrophage-specific knockout of ATP citrate lyase stabilized murine plaques and showed dysregulated cholesterol and fatty acid metabolism, main effects seemed to be exerted via changes in apoptosis ( Fumarate accumulation in -glucan trained monocytes increases histone methylation associated with an increased pro-inflammatory gene transcription of TNF and IL-6 (Liu et al., 2017)

Liao F, Yao C, Wu T, Chen S, Yeh L, Lin S, Lin W