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Recurrent phases of strict protein limitation inhibit tumor growth and restore lifespan in a drosophila intestinal cancer model

Zhu, M., Rhee, I., Liu, Y

2008 Jul;4(7):368-77

Cancer , 82 , 436440

Using a multiomics approach (i.e., transcriptomics, proteomics, and metabolomics), we showed that the circadian clock in the renal tubule strongly affects several key metabolic pathways in the kidney, including NAD + synthesis, -oxidation of fatty acids, carnitine handling, and mitochondrial activity