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Additionally, Kolligundla et al

Drug therapy: Phosphodiesterase 5 inhibitors Phosphodiesterase 5 (PDE5) is highly expressed in vascular smooth muscle and it is the most common PDE subtype in penile smooth muscle

Histidine (His) is a major N-donor ligand important for metal chelation in (metal hyperaccumulator) plants

However, studies have shown that specially designed nanodrugs can significantly avoid clearance by the kidneys and liver while effectively targeting the lymph nodes