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The global impact of diabetes is closely connected to the development of early insulin resistance, which stems from impaired signaling at the insulin receptor (INSR)

Published studies primarily focus on its interaction with enzymatic and metabolic pathways rather than endocrine signaling systems

Coordination Chemistry Reviews., 317 , 122131

Change history 22 October 2025 A Correction to this paper has been published: Abbreviations IPF: Idiopathic pulmonary fibrosis TGF-: Transforming growth factor- Nrf2: Nuclear factor erythroid 2related factor 2 SFN: Sulforaphane AMPK: AMP-activated protein kinase BCS: Bovine calf serum NQO-1: NAD(P)H quinone dehydrogenase 1 HO-1: Heme oxygenase 1 CaMKK2: Calcium-dependent protein kinase kinase 2 NOX4: NADPH oxidase 4 MDA: Malondialdehyde SOD: Superoxide dismutase GSH: Glutathione i.t