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demonstrated that single nucleotide polymorphisms (SNPs) of the AS3MT gene ought to be considered when determining the therapeutic dose of ATO, and that the urinary primary methylation index (PMI) can be used as a monitoring indicator of ATO-related chronic adverse reactions (AEs) (Zheng et al., 2021)

Nedd4-2 is also regulated by 14-3-3 proteins, which recognize phosphorylated motifs adjacent to the WW2 domain in response to hormones, such as aldosterone, insulin or vasopressin 25,26,27,28

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