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TB-500 is a synthetic peptide related to Thymosin Beta-4

It performs best as an adjunct, not a replacement

Transient and mostly mild-to-moderate gastrointestinal symptoms were the most frequently reported AE and occurred more frequently with the 4 mg starting dose groups rather than the 2 mg starting dose groups [67]

Combining it with another incretin agonist compounds GI and hypoglycemia risk with no supporting evidence, so the documented protocol is monotherapy