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These reflect both clinical demand and the limitations of what commercial products currently offer

Ive even read about people being permanently blinded by them

Transl Res (2010) 156:20715.10.1016/j.trsl.2010.06.001 43 VogelHJ

We identified FSP1 as this warfarin-insensitive vitamin K reductase, clarifying that the antidotal mechanism of vitamin K against warfarin overdose involves FSP1-mediated reduction of vitamin K, leading to the activation of coagulation factors even under warfarin poisoning [13, 51] (Fig

CD154/CD40 Another pair of co-stimulatory receptor-ligand system whose engagement has profound effects on B, dendritic and endothelial cells is the CD40-CD40 ligand (CD154)