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Most active research clusters in Philadelphia (2,072 recruiting) and Pittsburgh (1,325 recruiting), but the state has 171 cities running research sites, with smaller concentrations in Hershey (289), Danville (141), Allentown (134), Bethlehem (108), and plenty of others

Although HNPs have direct and potent antimicrobial activities, 185 these peptides also control infection during acute infection by modulating various immune activities such as chemotaxis, phagocytosis, and cytokine induction

Research-market products may not match historical study material

Both can become depleted through poor diet and aging

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