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In addition, microRNA-326 levels and high levels of glioma cells PKM2 are negatively correlated, indicating endogenous PKM2 adjustment mechanism

Dosing is extrapolated from preclinical models [1] [6]

whereas GPx3 is a secreted form found in plasma in various organs, and GPx4 (i.e

Krishnan J, Persons JL, Peu R, Hassan H, Kenzior A, Xiong S, Rohner N (2020) Comparative transcriptome analysis of wild and lab populations of Astyanax mexicanus uncovers differential effects of environment and morphotype on gene expression

Hence, the findings that tamoxifen resistance is associated with increased enolase I expression is consistent with the premise that tamoxifen selectively targets P-gp-expressing tumor cells which have higher ATP needs to fuel P-gp