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doi:10.1038/s4225502401155z

Polekhina G, Board PG, Gali RR, Rossjohn J, Parker MW: Molecular basis of glutathione synthetase deficiency and a rare gene permutation event

Methionine in the form of S-adenosylmethionine (SAM) is required for many methylation reactions, including DNA methylation

Maintenance dosing with 60 mg vials Once you have titrated to your target dose, the 60 mg vial becomes straightforward: At a 10 mg maintenance dose, you need roughly 9 vials per year