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The patient therefore was placed back on high dose Mepron (atovaquone) 2 teaspoons PO BID with azithromycin during her 3rd trimester for active relapsing babesiosis

Red flag symptoms requiring immediate evaluation include new grinding sounds after trauma, accompanied swelling lasting more than 48 hours, or inability to fully straighten the joint

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111 Another study has shown that the hypoxic environment upregulates the expression of HIF-1a, which activates the BMP4/SMAD signaling pathway, leading to an increase in ALP content and enhanced expression of osteogenic-related factors OCN and OPN, thereby promoting the osteogenic differentiation of BMSCs

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