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Rodas and colleagues demonstrated that regular low caffeine consumption induced a slight anti-inflammatory effect in healthy populations

This process is driven by PPAR activation, which induces the expression of lipid storage-associated genes, including DGAT and ACAT, thereby facilitating LDs biogenesis [100]

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Combined with adequate protein intake (widely recommended at 1.2-1.6g per kg of body weight during GLP-1 protocols) and resistance training, the higher dose ranges may actually preserve lean mass better than lower doses, because the energy deficit is being met predominantly through fat oxidation rather than muscle catabolism