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Another study of key barriers in Alzheimers disease research has indicated that enrollment challenges result in slower and more expensive trials, suggesting the need for nationally coordinated efforts to increase diverse participation in clinical trials in this and other disease areas (Malzbender et al., 2020)

PEGylation extends circulation half-life and reduces protein adsorption, yet anti-PEG antibodies can emergepromoting complement activation and rapid clearancewhich necessitates monitoring and the exploration of alternative stealth coatings (Ju et al., 2023