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doi: 10.1074/jbc.M117.796516 183 TanJKMcKenzieCMarioEMaciaLMackayCR

Damage to dopaminergic neurons by oxidative stress in Parkinson's disease

100 Despite the promising effect of CQ, 100 a recent phase I/II clinical trial combining HCQ with TMZ and radiation therapy, in patients with newly diagnosed GBM showed that the maximum tolerated dose of HCQ was unable to consistently inhibit autophagy and that dose-limiting toxicity prevented the possibility of moving to higher doses of HCQ

Mice were given flavocoxid at a dose of 20 mg/kg orally for 14 days, and a single dose (100 mg/kg, i.p) of cyclophosphamide on day 14

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