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This reaction catalyzes the generation of ROS, further promoting lipid peroxidation and leading to lipid peroxide accumulation, ultimately inducing ferroptosis (57) (Fig

Estrogen modulates brain function by enhancing cerebral blood flow, activating nerve growth factors, and preventing neuronal damage

Without specific biomarkers, it is difficult to evaluate the therapeutic effects of ferroptosis-targeting agents in clinical trials and adjust treatment plans accordingly

During the catalytic process, the level of cellular lipid peroxides directly affects the activity of enzymes, including cyclooxygenases (COXs) and LOXs