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A tissue-specific approach to the analysis of metabolic changes in Caenorhabditis elegans

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More importantly, the experiments of chemical inhibition and cKS were all carried out in RPMI -gln or RPMI Pgln medium containing ~5 times higher asparagine levels (378 M) than plasma (4080 M), suggesting that the extracellular asparagine could not compensate for the endogenous asparagine deficit in Pf caused by GS inhibition

The research was supported in part by the National Institute of General Medical Sciences (R35GM127045 awarded to S.L.S.), the NCIs Cancer Target Discovery and Development (CTD^2) Network (grant number U01CA217848 and U01CA272612 awarded to S.L.S.), and by the NIBR Scholars Program

Glutathion ist ein Tripeptid, das im menschlichen Krper berwiegend in der Leber aus den drei Aminosuren Glutaminsure, Cystein und Glycin gebildet wird und gehrt zu den wichtigsten zellulren Antioxidantien