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In phase 2 trials, cagrilintide alone produced dose-dependent reductions in body weight, with participants on the highest dose (4.5 mg weekly) losing roughly 10-15% of body weight over 26 weeks

Pembrolizumab and nivolumab which have also been in a category of immune checkpoint inhibitors are approved by FDA as a first line therapy in patients having cisplatin insensitive recurrent or metastatic HNSCC [19,20,21]