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10.1038/s41413-018-0016-9 104 GwonM.-G.AnH.-J.GuH.KimY.-A.HanS

Acta Anaesthesiol Scand

Hepatic blood flow is one of the determinants of hepatic clearance

It refers to all heritable alterations in gene expression and chromatin structure due to biochemical modifications that do not change the primary gene nucleotide sequence [2]

They observed that clinical symptoms of withdrawal disappeared or improved markedly and rapidly in 97% of inpatients with alcohol dependence and 87% of those with opiate dependence.19 Apart from headaches in a few, all patients tolerated the treatment well