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Bennie, J

Tirzepatide has an approved schedule starting at 2.5 mg once weekly, escalating in 2.5 mg steps at least four weeks apart, up to 15 mg once weekly

Strikingly, in the active structure of the c-MET/HGF dimeric complex, only HGF I simultaneously recruits two c-METs by using two distinct surfaces localized on the opposite sides of this HGF (Fig