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Although PENK aberrant methylation has been associated with BLCA tumorigenesis, the study revealed that NMIBC patients with PENK hypermethylation exhibited reduced recurrence-free survival rates, underscoring its clinical value also as a prognostic biomarker for follow-up care of BLCA patients [243]

111 In a recent study, the loss of tumor suppressor Merlin, a frequent tumourigenic event in mesothelioma, dictates GPx4 dependency in murine models of mesothelioma through the upregulation of multiple ferroptosis modulators, including ACSL4 and transferrin receptor

This suggests that hyh-derived membranes do not present physical or biochemical alterations interfering with -SNAP binding

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