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Increased oxidative stress and ROS overproduction may cause not only endothelial dysfunction but also programmed ECs death such as ferroptosis, pyroptosis, or necroptosis that are involved in the pathophysiology of many diseases, like COPD [78]

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Experience to date has shown that higher doses do not have any adverse effects on the unborn child

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10.1038/s41587-021-00933-4 [DOI] [PMC free article] [PubMed] [Google Scholar] 103