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With a goal of covering multiple biological systems to study effects on oxidation, the following models have been considered worth pursuing: Wild-type and mutant human GPX4 recombinant protein (available now at Karolinska Institute) CRISPR-edited GPX4 variant in reference cell lines (available now at Colombia University) SSMD patient-derived fibroblasts (available now at RUCDR Biorepository) SSMD patient-derived iPSC lines (available now at RUCDR Biorepository) Brain organoids derived from patient-derived iPSCs (not yet started) GPX4 conditional/complete knock-out mice (available now at JAX, Stock #027964) GPX4 condition knock-in mice (in-progress, ETA 1-Feb-2021) For genetic conditions, animal models are built by recreating the genetic variation in the animals genome or silencing the gene entirely

Elevated plasma marinobufagenin, an endogenous cardiotonic steroid, is associated with right ventricular dysfunction and nitrative stress in heart failure

Carboxytherapy is considered a safe, minimally invasive treatment when performed by trained medical professionals

Exp Mol Med 49(6):e349

Copp J-P, Desprez P-Y, Krtolica A, Campisi J