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When a ligand binds to the extracellular receptor, this initiates a signal transduction cascade that induces a conformational change, promoting the activation of the heterotrimeric GTP-binding protein (G-protein) (79)

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While it's not dangerous, it can be cosmetically bothersome for many. The best treatments, she says, combine chemical exfoliants [like AHAs and BHAs] and hydrating ingredients. That means look for salicylic, glycolic, or mandelic acid to break down keratin plugs, plus hydrators like hyaluronic acid and ceramides to strengthen the skin barrier