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Synovial inflammation promotes osteoarthritis

The proposed mechanism is that TPS1 derepresses genes involved in nitrate utilization via NMR1

D., Denome, S

Notably, mPTP opening represents a critical decision point in cell fate: transient, low-conductance openings serve physiological roles in Ca 2+ homeostasis, whereas sustained, high-conductance opening exceeding the point of no return inevitably leads to mitochondrial swelling, outer membrane rupture, and cell death via apoptosis or necrosis (94)