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Here, dasatinib was conjugated through an ester coupling to the carboxylic-acid arm of MHI-148 ( Figure 6 , C5 )
This system demonstrated a 200% improvement in drug diffusion through the stroma compared to free drug combinations by downregulating fibrosis-associated proteins and inhibiting cancer-associated fibroblasts (CAFs)
The FDA recently approved another JAK inhibitor drug developed by Incyte, baricitinib, which is a pill taken to treat hair loss caused by alopecia areata
Free Radic Biol Med (2005) 38(12):154352
[50] designed an innovative PS structure, TPATrzPy-3 + , based on aggregation-induced emission (AIE) characteristics, and successfully fabricated PMOF using Cu-MOFs as the carrier (Fig
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