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Despite the administration of optimal treatments, including radical surgical resection in conjunction with standard radiotherapy and chemotherapy, patients with GBM have a median survival duration of only ~16 months following diagnosis (5)

Based on results thus far, we postulated the following model: while K48-linked ubiquitylation by UBR5 is restricted by OTUD5, TRIP12 assembles K29-linked chains, which are resistant to OTUD5 DUB activity

Proc Natl Acad Sci U S A (2017) 114(38):102149