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Enhancing MSC stress adaptability through pharmacological or factor interventions may provide new strategies for improving the efficacy of cell transplantation therapy for IDD

Malondialdehyde (MDA) levels in each group were determined using the Lipid Peroxidation MDA Assay Kit (Beyotime, China), according to the manufacturers instructions

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In addition to normal tissues, it has been reported that GPx2 is upregulated in a variety of tumor cells [76, 95] and is associated with tumor cell proliferation and poor prognosis of patients [96, 97]

J Neurochem 66:18761881 Saito Y, Nishio K, Numakawa Y, Ogawa Y, Yoshida Y, Noguchi N, Niki E (2007) Protective effects of 15-deoxy-12,14-prostaglandin J2 against glutamate-induced cell death in primary cortical neuron cultures: induction of adaptive response and enhancement of cell tolerance primarily through up-regulation of cellular glutathione