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Acta 1802 , 4551 (2010)

doi: 10.1016/0896-6273(92)90167-C 34 BivilleF.BrzillonC.GiorginiD.TahaM.-K

Data suggests a short half-life and bioavailability of about 30% due to certain mechanisms, including hepatic degradation, reduced solubility as well as instability in the stomach [91]

256 However, in various clinical trials investigating its antitumor efficacy, siltuximab monotherapy demonstrated limited clinical activity, prompting a strategic shift toward exploring its role in combination therapies