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The mechanisms are different and do not directly conflict, but absence of conflict is not the same as evidence of benefit

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Understanding Sciatica: More Than Just a "Pinched Nerve" Sciatica occurs when the sciatic nerve becomes irritated or compressed, often due to disc injury, joint instability, muscle tension, or inflammation around the nerve root

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Wild-type C57BL/6 mice, After a week of intraperitoneal injection with the CD38 inhibitor 1 (compound 78c) at a dose of 15 mg/kg every 2 days, a single intraperitoneal (i.p.) injection of LPS was administered 24 h after the last dose