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In this study, we provide a comprehensive clinical and neuropathologic characterization of an APP V717I mutation carrier, shedding new light on the phenotypic variability observed in ADAD cases (Lloyd et al., 2020)

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Elevated levels of reactive oxygen species (ROS) in osteoarthritic joints can directly damage proteins, lipids, and nucleic acids, triggering several cell death pathways, including apoptosis, pyroptosis, and autophagy-related cell death (16)