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Many women with PCOS develop insulin resistance, a condition where the body's cells become less responsive to insulin, leading to elevated blood glucose and insulin levels

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Suitable polymerizable functional groups present on the crosslinker reagent include primary and secondary amino, carboxylic acid and derivatives, maleimide, thiol, hydroxyl and other alpha,beta unsaturated Michael acceptors such as vinylsulfone groups, preferably terminal primary or secondary amino, carboxylic acid and derivatives, maleimide, thiol, hydroxyl and other alpha,beta unsaturated Michael acceptors such as vinylsulfone groups

doi: 10.1002/mds.25585

Regarding plasma protein binding, most of the compounds showed more than 90% binding except for 1, 2, 7, 12, 15, 18, 29, 36, 37, 39, 42, 51, and 58