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The excessive production of lactate is often accompanied by an increase in mitochondrial reactive oxygen species (ROS) and altered iron metabolism [129, 133]

It is characterised by genetic and autoimmune components, with hyperactivation of the immune system and an inflammatory cycle that self-sustains developing around the TNF/IL-23/IL-17 axis [47]

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The ADOS is a semi-structured assessment administered by a trained assessor that consists of various activities that allow the observation of social and communication behaviors related to the diagnosis of ASD (43)