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Further to this point, BRAF V600E -mutated PA are prevalent in diencephalic areas in particular in unresectable hypothalamic/optic pathway PA, in contrast to KIAA1549-BRAF fusion-positive PA, which are prevalent in the cerebellum ( V600E is more frequently associated with non-progression, and KIAA1549-BRAF fusion was more common in progressive tumors ( BRAF-mutated diencephalic LGGs rarely present malignant transformation, but because they are usually unresectable, novel targeted therapy is strongly warranted

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