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CBA mice also maintain normal auditory function until late in life 25,26,27

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Early symptoms of Parkinsons disease include: A slight tremor in one hand Shrinking handwriting Reduced sense of smell Sleep disrupted with night terrors and violent thrashing Reduced balance Stiffness when moving or walking Chronic constipation Mask of Parkinsons marked by staring and loss of emotional facial expression As the disease advances, symptoms become increasingly severe and unmanageable, and loved ones are often faced with difficult decisions for long-term care