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Pharmacotherapy [12, 13] consists of four categories of drugs: (1) First-line drugs like anticonvulsants (gabapentin, pregabalin, and carbamazepine) and antidepressants (amitriptyline, duloxetine, and venlafaxine)

In this Review, we (1) summarize recent advances concerning the role of metabolic dysregulation during atherosclerosis progression in lesional cells, including endothelial cells, vascular smooth muscle cells, macrophages and T cells

Funding This study was supported, in part, by research grants from Shenzhen Peacock Plan (No

Clinical evidence comes in tiers: mechanistic studies (does the molecule do what it should at the cellular level?), animal studies (does it produce the expected effect in a living organism?), and human trials (does it actually work on the people who will use it?)

however, the use of mainly artificial assay systems makes interpretation difficult and few reports document direct pathogenic proteinenzyme interactions within a specific intact cell type