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These genotoxic insults can result in point mutations, chromosomal aberrations, and microsatellite instability, which are recognized as molecular hallmarks of early-stage carcinogenesis [24,25]

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However, the definite STAT3 binding sites were only confirmed in the promoter regions of PSMB8 and PSMB9 41 , while PPI could make other proteasome subunits downregulated

A 3-mm horizontal cut was made on the left liver lobe using a surgical blade (#20)