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Research on people susceptible to high-altitude pulmonary edema found that patients with elevated pulmonary artery pressure in high-altitude environments had increased free radical production and transpulmonary output in pulmonary blood vessels, increased pro-inflammatory cytokine production, and decreased NO bioavailability, suggesting that HAPH is related to free radical-mediated reduction in NO bioavailability [72]

All it means is that a doctor is prescribing a medication for a different purpose than what the FDA originally approved it for

Magnetic resonance imaging, fluorescence imaging, single-photon emission computed tomography (SPECT), computed tomography, positron emission tomography (PET), and ultrasound imaging is the currently available techniques that may identify probe/folic acid conjugates