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Another commenter disagreed, saying that the relative complexity of CPT code 66683 as compared to CPT code 66682 is significantly greater than the 1.93 work RVU difference as noted by the RUC and in the proposed work RVUs for CPT codes 66682 and 66683

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However, tumor heterogeneity and immune pressure often drive antigen loss or clonal evolution, limiting the effectiveness of approaches that rely on a narrow antigen pool