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The Kraus 2014 study reported that adipocyte-specific NNMT knockdown in mice increased adipocyte energy expenditure through a mechanism interpreted as elevated methyl-donor availability for polyamine biosynthesis and for histone methylation that modulates adipocyte gene-expression programs [2]

Studies with these compounds require institutional oversight and safety protocols

An essential vitamin yes but it often played second fiddle to vitamin C, D and Omega-3

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